Homocystiene, an intermediate in the synthesis of methionine, can build up in the blood if important B vitamins are lacking in the diet. Homocysteine levels can then increase to the point where it can play a significant role in increasing the risk of cardiovascular disease.
Source: Designs for Health, Dietary Folate and Vitamin B6 and B12 Intake in Relation to Mortality From Cardiovascular Diseases. Japan Collaborative Cohort Study
I recommend taking an Isotonix B-Complex Vitamin, which includes folate. Click here to learn more about this supplement.